治疗性高眼压症患者视神经的形态功能随访：视盘形态测量与稳态图形视网膜电图
Morpho-functional follow-up of the optic nerve in treated ocular hypertension: disc morphometry and steady-state pattern electroretinogram.
作者信息
Salgarello Tommaso, Falsini Benedetto, Stifano Giovanna, Montrone Lucrezia, Iarossi Giancarlo, Balestrazzi Emilio, Colotto Alberto
机构信息
Institute of Ophthalmology, Catholic University of Sacred Heart, Rome, Italy.
出版信息
Curr Eye Res. 2008 Aug;33(8):709-21. doi: 10.1080/02713680802277692.
PURPOSE
To examine longitudinally optic disc structure and inner retinal function in treated ocular hypertension (OHT).
MATERIALS AND METHODS
A morphometric (Heidelberg Retina Tomograph, HRT) and functional (steady-state pattern electroretinogram, PERG) evaluation of 27 OHT patients treated with topical beta-blockers and/or prostaglandin analogues and prospectively followed over a 24 +/- 6 month period.
RESULTS
Compared with baseline, mean final PERG amplitude tended to increase (p < 0.01), while HRT was stable. Individual PERG amplitude increase was large (>or= 100%) in some patients (5/27), and unexplained by clinical parameters at baseline.
CONCLUSIONS
In treated OHT, functional responses may improve while disc structure remains stable. The findings suggest that OHT-associated inner retinal dysfunction is at least in part reversible with therapeutic intraocular pressure control.
目的
纵向观察治疗性高眼压症（OHT）患者的视盘结构和视网膜内层功能。
材料与方法
对27例接受局部β受体阻滞剂和/或前列腺素类似物治疗的OHT患者进行形态学（海德堡视网膜断层扫描，HRT）和功能（稳态图形视网膜电图，PERG）评估，并前瞻性随访24±6个月。
结果
与基线相比，最终平均PERG振幅有增加趋势（p<0.01），而HRT保持稳定。部分患者（5/27）的个体PERG振幅增加幅度较大（≥100%），且无法用基线时的临床参数解释。
结论
在治疗性OHT中，功能反应可能改善，而视盘结构保持稳定。这些发现提示，与OHT相关的视网膜内层功能障碍至少部分可通过治疗性眼压控制得到逆转。
Zotero 插件