Creaven P J, Stoll H L
Department of Medicine, Roswell Park Cancer Institute, New York State Department of Health, Buffalo 14263.
J Am Acad Dermatol. 1991 May;24(5 Pt 1):735-7. doi: 10.1016/0190-9622(91)70112-f.
A 70-year-old woman was treated for renal cell carcinoma with recombinant human tumor necrosis factor, 450,000 U/m2 of body surface area, daily for 5 days, once a month. She had had psoriasis for 25 years. After two courses of recombinant human tumor necrosis factor her psoriasis resolved. A 40-year-old man with severe psoriasis was subsequently treated with a total of seven complete and incomplete 5-day courses of recombinant human tumor necrosis factor at doses of 50,000 to 300,000 U/m2/day. Significant toxicity (fever, chills, hypertension, and hypotension) was encountered. Partial resolution of the lesions was seen. Tumor necrosis factor is an active agent in psoriasis.
一名70岁女性因肾细胞癌接受重组人肿瘤坏死因子治疗，剂量为450,000 U/m²体表面积，每日一次，共5天，每月一次。她患银屑病已25年。经过两个疗程的重组人肿瘤坏死因子治疗后，她的银屑病得到缓解。一名40岁重度银屑病男性患者随后接受了总共七个完整和不完整的5天疗程的重组人肿瘤坏死因子治疗，剂量为50,000至300,000 U/m²/天。出现了明显的毒性反应（发热、寒战、高血压和低血压）。病变部分缓解。肿瘤坏死因子是银屑病的一种活性剂。
