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Inhibition of hERG channel trafficking: an under-explored mechanism for drug-induced QT prolongation.

作者信息

Yeung Kap-Sun, Meanwell Nicholas A

机构信息

Bristol-Myers Squibb Research and Development, 5 Research Parkway, P.O.Box 5100, Wallingford, CT 06492, USA.

出版信息

ChemMedChem. 2008 Oct;3(10):1501-2. doi: 10.1002/cmdc.200800170.

DOI:10.1002/cmdc.200800170
PMID:18696522
Abstract
摘要

相似文献

1
Inhibition of hERG channel trafficking: an under-explored mechanism for drug-induced QT prolongation.抑制人醚-去极化激活的钾离子通道（hERG）转运：药物诱导QT间期延长的一种未充分探索的机制。
ChemMedChem. 2008 Oct;3(10):1501-2. doi: 10.1002/cmdc.200800170.
2
Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.药物诱导的长QT综合征：氟西汀和去甲氟西汀对人乙醚-a- go-go相关基因（hERG）钾通道的阻滞及蛋白质转运的破坏
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hERG: protein trafficking and potential for therapy and drug side effects.人醚-去极化激活的钾离子通道：蛋白质转运以及治疗潜力和药物副作用
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hERG channel trafficking: novel targets in drug-induced long QT syndrome.人乙醚 - 去极化相关基因（hERG）通道转运：药物性长QT综合征的新靶点
Biochem Soc Trans. 2007 Nov;35(Pt 5):1060-3. doi: 10.1042/BST0351060.
5
Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology.氟西汀对药物诱导的长QT综合征中hERG通道的联合抑制及转运破坏作用：心脏安全药理学的一项案例研究
Br J Pharmacol. 2006 Nov;149(5):457-9. doi: 10.1038/sj.bjp.0706890. Epub 2006 Sep 11.
6
Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.酮康唑诱发长QT综合征中hERG电流阻滞与蛋白质转运障碍的共存
Br J Pharmacol. 2008 Feb;153(3):439-47. doi: 10.1038/sj.bjp.0707537. Epub 2007 Oct 29.
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Evidence for a crucial modulating role of the sodium channel in the QTc prolongation related to antipsychotics.钠通道在抗精神病药物相关的QTc延长中起关键调节作用的证据。
J Psychopharmacol. 2014 Apr;28(4):329-40. doi: 10.1177/0269881113515064. Epub 2013 Dec 10.
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hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia.药物诱导的致死性心律失常中的人醚 - 去极化激活钾离子通道（hERG）转运抑制
Eur J Pharmacol. 2014 Oct 15;741:336-9. doi: 10.1016/j.ejphar.2014.06.044. Epub 2014 Jul 3.
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QT interval prolongation and cardiac risk assessment for novel drugs.新型药物的QT间期延长与心脏风险评估
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Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656.抗组胺药溴苯那敏对HERG钾通道的阻断需要通道与S6残基Y652和F656内结合。
J Appl Toxicol. 2008 Mar;28(2):104-11. doi: 10.1002/jat.1252.

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Computational insights into the mechanisms underlying structural destabilization and recovery in trafficking-deficient hERG mutants.对运输缺陷型hERG突变体结构不稳定和恢复潜在机制的计算洞察。
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Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti-seizure medication: Levetiracetam case study.用已确立的抗癫痫药物测试非临床全面体外致心律失常试验（CiPA）范式：左乙拉西坦案例研究。
Pharmacol Res Perspect. 2023 Feb;11(1):e01059. doi: 10.1002/prp2.1059.
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Targeted Cancer Therapies and QT Interval Prolongation: Unveiling the Mechanisms Underlying Arrhythmic Complications and the Need for Risk Stratification Strategies.
靶向癌症治疗与QT间期延长：揭示心律失常并发症的潜在机制及风险分层策略的必要性
Clin Drug Investig. 2017 Feb;37(2):121-134. doi: 10.1007/s40261-016-0460-5.
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Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.多种机制导致 hERG 相关不良反应：阿莫沙平抑制钾电流、破坏蛋白转运和诱导细胞凋亡。
Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. doi: 10.1007/s00210-010-0496-7. Epub 2010 Mar 13.
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Ion channel trafficking: a new therapeutic horizon for atrial fibrillation.离子通道运输：心房颤动治疗的新领域。
Heart Rhythm. 2010 Sep;7(9):1309-15. doi: 10.1016/j.hrthm.2010.02.017. Epub 2010 Feb 13.
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Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells.异喹啉生物碱甲基莲心碱对稳定转染的HEK293细胞中HERG钾通道的阻断作用
Naunyn Schmiedebergs Arch Pharmacol. 2009 Aug;380(2):143-51. doi: 10.1007/s00210-009-0419-7. Epub 2009 May 8.