Pokorný J, Hasek J, Vanis J, Jelínek F
Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberski 57, 18251 Prague 8, Czech Republic.
Indian J Exp Biol. 2008 May;46(5):310-21.
Hypothesis of coherent vibration states in biological systems based on nonlinear interaction between longitudinal elastic and electric polarization fields with metabolic energy supply was formulated by Frohlich. Conditions for excitation of coherent states and generation of electromagnetic fields are satisfied in microtubules which form electrical polar structures. Numerical models are used for analysis of Frohlich's vibration states in cells. Reduction of activity and of energy production in mitochondria, and disintegration of cytoskeleton structures by phosphorylation on the pathway of cancer trasformation can diminish excitation of the Frohlich's vibration states and of the generated electromagnetic field, which results in disturbances of the interaction forces between cells. Interaction forces between cancer cells may be smaller than interaction forces between healthy cells and cancer cells as follows from numerical models. Mechanism of malignity, i.e. local invasion, detachment of cancer cells, and metastasis, is assumed to depend on the electromagnetic field.
弗罗利希提出了基于纵向弹性极化场与电场极化场之间的非线性相互作用以及代谢能量供应的生物系统相干振动状态假说。形成电极化结构的微管满足相干态激发和电磁场产生的条件。数值模型用于分析细胞中的弗罗利希振动状态。在癌症转化过程中,线粒体活性和能量产生的降低以及细胞骨架结构因磷酸化而解体,可能会减少弗罗利希振动状态和所产生电磁场的激发,从而导致细胞间相互作用力的紊乱。从数值模型可以看出,癌细胞之间的相互作用力可能小于健康细胞与癌细胞之间的相互作用力。恶性肿瘤的机制,即局部侵袭、癌细胞脱离和转移,被认为取决于电磁场。