神经元中的细胞内肾素-血管紧张素系统：事实、假说还是幻想？
An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.
作者信息
Grobe Justin L, Xu Di, Sigmund Curt D
机构信息
Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
出版信息
Physiology (Bethesda). 2008 Aug;23:187-93. doi: 10.1152/physiol.00002.2008.
Abstract
The renin-angiotensin system in the brain acts to regulate a number of physiological processes. Evidence suggests that angiotensin peptides may act as neurotransmitters, although their biosynthetic pathways are poorly understood. We review evidence for neuronal production of angiotensin peptides and hypothesize that angiotensin may be synthesized intracellularly in neurons.
摘要
大脑中的肾素-血管紧张素系统作用于调节多种生理过程。有证据表明，血管紧张素肽可能作为神经递质发挥作用，尽管其生物合成途径尚不清楚。我们综述了血管紧张素肽由神经元产生的证据，并推测血管紧张素可能在神经元内进行胞内合成。
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