钠钾ATP酶与钙信号微区
The Na-K-ATPase and calcium-signaling microdomains.
作者信息
Tian Jiang, Xie Zi-jian
机构信息
Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, Ohio, USA.
出版信息
Physiology (Bethesda). 2008 Aug;23:205-11. doi: 10.1152/physiol.00008.2008.
Abstract
The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.
摘要
钠钾ATP酶是一种能量转换离子泵，可将ATP的自由能转化为跨膜离子梯度。它还作为哇巴因和地高辛等强心甾类的功能性受体。哇巴因与钠钾ATP酶的结合可通过细胞特异性方式激活钙信号传导。通过钠钾ATP酶实现的精细钙调节是通过该泵整合来自众多蛋白质和非蛋白质分子（包括离子转运体、通道、蛋白激酶/磷酸酶以及细胞内钠离子）信号的能力来实现的。本综述聚焦于钠钾ATP酶的独特性质及其在不同钙信号微域形成中的作用。
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