Sanger Jean M, Sanger Joseph W
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA.
Sci Signal. 2008 Aug 12;1(32):pe37. doi: 10.1126/scisignal.132pe37.
The distribution of proteins in the sarcomeres of skeletal and cardiac muscle gives rise to the striated pattern of these muscles. Sarcomeric protein localization is not, however, permanently fixed. There is dynamic exchange of proteins between a cytosolic pool and the sarcomere, addition of newly synthesized proteins during development and repair, and aberrant redistribution of proteins due to mutations. Recent studies have shown that two groups of proteins that localize in the sarcomere Z band can relocate, in one case to the A band, and in the other to the nucleus.
骨骼肌和心肌肌节中蛋白质的分布形成了这些肌肉的条纹状图案。然而，肌节蛋白的定位并非永久固定。在胞质池和肌节之间存在蛋白质的动态交换，在发育和修复过程中有新合成蛋白质的添加，以及由于突变导致的蛋白质异常重新分布。最近的研究表明，两组定位于肌节Z带的蛋白质可以重新定位，一种情况是定位到A带，另一种情况是定位到细胞核。
