Osika Walter, Montgomery Scott M
Department of Cardiology, Orebro University Hospital, SE-701 85 Orebro, Sweden.
BMJ. 2008 Aug 12;337:a699. doi: 10.1136/bmj.a699.
To identify whether measures of childhood physical control and coordination as markers of neurological function are associated with obesity in adults.
Longitudinal birth cohort study.
National child development study in Great Britain.
11,042 people born during one week in 1958.
Obesity at age 33 years defined as body mass index >or=30.
Among 7990 cohort members at age 7 years, teachers reported that poor hand control, poor coordination, and clumsiness "certainly applied" more often among those who would be obese adults, producing adjusted odds ratios of 1.57 (95% confidence interval 1.13 to 2.20; P=0.008) for poor hand control, 2.30 (1.52 to 3.46; P<0.001) for poor coordination, and 3.91 (2.61 to 5.87; P<0.001) for clumsiness. Among 6875 participants who had doctor administered assessments with continuous scores at age 11 years, poorer function was associated with later obesity, indicated by adjusted odds ratios (change in risk per unit increase in score) of 0.88 (0.81 to 0.96; P=0.003) for copying designs, 0.84 (0.78 to 0.91; P<0.001) for marking squares, and 1.14 (1.06 to 1.24; P<0.001) for picking up matches (a higher score indicates poor function in this test). Further adjustment for contemporaneous body mass index at age 7 or 11 years did not eliminate statistical significance for any of the associations.
Some aspects of poorer neurological function associated with adult obesity may have their origins in childhood.
确定作为神经功能标志物的儿童身体控制和协调能力指标是否与成人肥胖有关。
纵向出生队列研究。
英国全国儿童发展研究。
1958年某一周内出生的11042人。
33岁时的肥胖定义为体重指数≥30。
在7990名7岁的队列成员中，教师报告称，手部控制能力差、协调性差和动作笨拙在未来会成为肥胖成人的儿童中更为常见，手部控制能力差的调整后比值比为1.57（95%置信区间1.13至2.20；P = 0.008），协调性差的为2.30（1.52至3.46；P < 0.001），动作笨拙的为3.91（2.61至5.87；P < 0.001）。在6875名11岁时接受医生连续评分评估的参与者中，功能较差与日后肥胖相关，复制图案的调整后比值比（分数每增加一个单位的风险变化）为0.88（0.81至0.96；P = 0.003），画方格的为0.84（0.78至0.91；P < 0.001），捡起火柴的为1.14（1.06至1.24；P < 0.001）（该测试中分数越高表明功能越差）。对7岁或11岁时的同期体重指数进行进一步调整后，任何关联的统计学意义均未消除。
与成人肥胖相关的神经功能较差的某些方面可能始于儿童期。
