Hellerstein Stanley, Chambers Luke
Section of Nephrology, Department of Pediatrics, Children's Mercy Hospital, The University of Missouri-Kansas City School of Medicine, Kansas City 64108, USA.
Clin Pediatr (Phila). 2008 Sep;47(7):652-8. doi: 10.1177/0009922808315661.
The study provides the pediatric practitioner with a tool to determine whether the child with an apparently normal solitary kidney requires an in-depth investigation. Medical records from January 1, 1995 to December 31, 2006 identified 96 children with solitary kidneys and showed 78 with a normal appearing, hypertrophied solitary kidney. Study groups included (1) children 1 to 2 years, (2) girls older than 2 years and boys 2 to 13 years, and (3) boys older than 13 years. Serum creatinine concentrations and estimated glomerular filtration rate were calculated for each group. The mean serum creatinine concentrations in group 1 was 0.4+/-0.1 mg/dL, group 2 was 0.6+/-0.2 mg/dL, and group 3 was 1.1+/-0.2 mg/dL. An estimated glomerular filtration rate 2 SD below the mean suggests further investigation. An estimated glomerular filtration rate 2 SD below the mean was 78 mL/min/1.73 m(2) in group 1, 73 mL/min/1.73 m(2) in group 2, and 70 mL/min/1.73 m(2) in group 3.
该研究为儿科医生提供了一种工具，用于确定看似正常的单肾儿童是否需要进行深入检查。1995年1月1日至2006年12月31日的病历记录识别出96名单肾儿童，其中78名单肾外观正常且肥大。研究组包括：（1）1至2岁的儿童；（2）2岁以上的女孩和2至13岁的男孩；（3）13岁以上的男孩。计算了每组的血清肌酐浓度和估计肾小球滤过率。第1组的平均血清肌酐浓度为0.4±0.1mg/dL，第2组为0.6±0.2mg/dL，第3组为1.1±0.2mg/dL。估计肾小球滤过率低于平均值2个标准差表明需要进一步检查。第1组估计肾小球滤过率低于平均值2个标准差为78mL/min/1.73m²，第2组为73mL/min/1.73m²，第3组为70mL/min/1.73m²。
