Kumar D Maneesh, Simpkins James W, Agarwal Neeraj
Department of Cell Biology, UNT Health Science Center, Fort Worth, TX 76107, USA.
Mol Vis. 2008 Aug 11;14:1480-6.
Estrogens play a critical role in the normal growth and development of humans and in recent years our understanding of their effects in the central nervous system (CNS) have been advancing rapidly. It is now known that estrogens influence synaptic plasticity, brain development, and memory. In addition, estrogens have been shown to be neuroprotective in degenerative disorders. The understanding of the influences of estrogens in the retina, as a component of the CNS, has not kept pace with the advances in understanding of the brain. Studies that have addressed the effects of estrogens on the retina, specifically those focusing on glaucoma, are examined here in the hope that estrogen therapy may be a viable option for treating retinal dystrophies and optic neuropathies.
雌激素在人类正常生长发育中发挥着关键作用，近年来，我们对其在中枢神经系统（CNS）中的作用的理解迅速发展。现在已知雌激素会影响突触可塑性、大脑发育和记忆。此外，雌激素已被证明在退行性疾病中具有神经保护作用。作为中枢神经系统的一个组成部分，对雌激素在视网膜中的影响的理解尚未跟上对大脑理解的进展。本文审视了研究雌激素对视网膜影响的相关研究，特别是那些聚焦于青光眼的研究，希望雌激素疗法可能成为治疗视网膜营养不良和视神经病变的可行选择。
