基于咪唑的和厚朴酚类似物的合成与体外评价
Synthesis and in vitro evaluation of imidazole-based wakayin analogues.
作者信息
Hoang Hung, Huang Xiaofen, Skibo Edward B
机构信息
Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA.
出版信息
Org Biomol Chem. 2008 Sep 7;6(17):3059-64. doi: 10.1039/b806883f. Epub 2008 Jul 16.
DOI:10.1039/b806883f
PMID:18698463
Abstract
Analogues of wakayin based on diimidazo[1,5,4-de, 1,5,4-h]-quinoxaline have been prepared and evaluated with respect to cytostatic and cytotoxic activity. Assays in a 60-cell-line human cancer panel revealed selective activity against cells with the VEGF (Flt-1) receptor.
摘要
已制备了基于二咪唑并[1,5,4 - de,1,5,4 - h] - 喹喔啉的和歌因类似物，并对其细胞生长抑制和细胞毒性活性进行了评估。在一个60种细胞系的人类癌症组中的检测显示，其对具有VEGF（Flt - 1）受体的细胞具有选择性活性。
Zotero 插件