新型二氢苯并呋喃-咪唑杂合化合物的设计、合成及细胞毒性活性。
Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole.
机构信息
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.
出版信息
Org Biomol Chem. 2011 Jun 7;9(11):4250-5. doi: 10.1039/c1ob05116d. Epub 2011 Apr 20.
A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.
已经合成了一系列新型二氢苯并呋喃和咪唑的混合化合物，并对其进行了体外评估，以检测其对一组人类肿瘤细胞系的抑制活性。结果表明，咪唑 1 位取代供电子的二氢苯并呋喃，以及咪唑 3 位取代萘甲酰基或富电子的苯甲酰基，对于调节细胞毒性活性至关重要。
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