Groenendaal Bas, Ruijter Eelco, de Kanter Frans J J, Lutz Martin, Spek Anthony L, Orru Romano V A
Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.
Org Biomol Chem. 2008 Sep 7;6(17):3158-65. doi: 10.1039/b807138a. Epub 2008 Jul 3.
Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences.
三嗪烷二酮可通过最近报道的多组分反应轻松生成，能与各种卤代烃轻松发生烷基化反应，从而实现各种各样能产生复杂性的二次反应。由于初始多组分反应的高度可变性以及取代基参与二次反应的多种可能性，在简短且高效的反应序列中获得了高度多样的复杂产物。
