Groenendaal Bas, Vugts Danielle J, Schmitz Rob F, de Kanter Frans J J, Ruijter Eelco, Groen Marinus B, Orru Romano V A
Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands
J Org Chem. 2008 Jan 18;73(2):719-22. doi: 10.1021/jo701973d. Epub 2007 Dec 21.
An efficient, one-pot synthetic protocol toward triazinane diones, a rather unexplored class of heterocyclic scaffolds combining phosphonates, nitriles, aldehydes, and isocyanates is described. The optimization of the reaction, synthesis of a small library of different triazinane diones, as well as alternative routes toward the triazinane dione scaffold are discussed.
本文描述了一种高效的一锅法合成三嗪烷二酮的方案，三嗪烷二酮是一类尚未充分探索的杂环骨架，它结合了膦酸酯、腈、醛和异氰酸酯。文中讨论了反应的优化、不同三嗪烷二酮的小型库的合成以及通往三嗪烷二酮骨架的替代路线。
