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The degradation pathways in chloride medium of the third generation anticancer drug oxaliplatin.

作者信息

Alberto Marta E, Lucas Maria F, Pavelka Matej, Russo Nino

机构信息

Dipartimento di Chimica, Università della Calabria - Via P. Bucci, cubo 14c, 87036 Arcavacata di Rende (CS), Centro di Calcolo ad Alte Prestazioni per Elaborazioni Parallele e Distribuite - Centro d'Eccellenza MIUR, Italy.

出版信息

J Phys Chem B. 2008 Sep 4;112(35):10765-8. doi: 10.1021/jp800476b. Epub 2008 Aug 12.

DOI:10.1021/jp800476b
PMID:18698718
Abstract

We have investigated the degradation reactions, in chloride medium, of the third generation drug oxaliplatin using density functional theory. Our calculations confirm that this drug should be administered in chloride free solutions, and we have ascertained the main biodegradation products upon chloride binding, which are essential to establish the active compounds reacting with DNA. In addition, detailed knowledge of these platinum complexes is fundamental for correct elimination procedures in wastewater treatments.

摘要

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