Andersson Johanna, Li Shiming, Lincoln Per, Andréasson Joakim
Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
J Am Chem Soc. 2008 Sep 10;130(36):11836-7. doi: 10.1021/ja801968f. Epub 2008 Aug 13.
The dramatically different DNA-binding properties of the two isomeric forms of a photochromic spiropyran have been demonstrated, enabling photoswitched DNA binding. The closed, UV-absorbing form shows no signs of interaction with DNA. Upon UV exposure the spiropyran is isomerized to the open form that binds to DNA by intercalation. The process is fully reversible as the corresponding dissociation process is induced by visible light.
一种光致变色螺吡喃的两种异构体形式具有显著不同的DNA结合特性，这已得到证实，从而实现了光开关DNA结合。封闭的、吸收紫外线的形式没有显示出与DNA相互作用的迹象。在紫外线照射下，螺吡喃异构化为开放形式，通过嵌入与DNA结合。由于相应的解离过程由可见光诱导，该过程是完全可逆的。
