Restorp Per, Rebek Julius
The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA.
J Am Chem Soc. 2008 Sep 10;130(36):11850-1. doi: 10.1021/ja803854r. Epub 2008 Aug 13.
A deep cavitand with an inwardly directed carboxylic acid function reacts with small aliphatic isonitriles to form N-acyl formamides inside the cavity. The unique isolation and stabilization of covalently bound guests within the structured environment of the cavitand allows for observation of the labile O-acyl isoimide intermediate using conventional spectroscopic methods.
一种带有向内羧酸官能团的深穴体与小脂肪族异腈反应，在穴腔内形成N-酰基甲酰胺。穴体结构环境内共价结合客体的独特隔离和稳定作用，使得可以使用传统光谱方法观察不稳定的O-酰基异亚胺中间体。
