Robertson Mary M, Althoff Robert R, Hafez Adam, Pauls David L
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.
Br J Psychiatry. 2008 Jul;193(1):31-6. doi: 10.1192/bjp.bp.107.039909.
Tourette syndrome is a heterogeneous familial disorder for which the genetic mechanisms are unknown. A better characterisation of the phenotype may help identify susceptibility genes.
To extend previous factor-analytic studies of the syndrome.
Symptom data from 410 people with Tourette syndrome were included in agglomerative hierarchical cluster and principal components analyses.
Five factors were observed, characterised by: (1) socially inappropriate behaviours and other complex vocal tics; (2) complex motor tics; (3) simple tics; (4) compulsive behaviours; and (5) touching self. Individuals with co-occurring attention-deficit hyperactivity disorder had significantly higher factor scores on Factors 1 and 3, whereas individuals with co-occurring obsessive-compulsive disorder and behaviours had significantly higher factor scores for Factors 1-4.
These findings add to the growing body of evidence that Tourette syndrome is not a unitary condition and can be disaggregated into more homogeneous symptom components.
抽动秽语综合征是一种遗传机制不明的异质性家族性疾病。对该综合征表型进行更深入的描述可能有助于识别易感基因。
扩展先前对该综合征的因素分析研究。
将410例抽动秽语综合征患者的症状数据纳入凝聚层次聚类分析和主成分分析。
观察到五个因素，其特征分别为：（1）社交不适当行为及其他复杂发声抽动；（2）复杂运动抽动；（3）简单抽动；（4）强迫行为；（5）自我触摸。同时患有注意力缺陷多动障碍的个体在因素1和因素3上的得分显著更高，而同时患有强迫症及相关行为的个体在因素1至因素4上的得分显著更高。
这些发现进一步证明了抽动秽语综合征并非单一病症，可细分为更具同质性的症状成分。
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