Constans T, Dutertre J P, Frogé E
Hôpital de l'Ermitage, Tours, France.
J Palliat Care. 1991 Summer;7(2):10-2.
Dehydration is frequently encountered in elderly patients and hypodermoclysis is an alternative method of parenteral rehydration. Hyaluronidase is classically added to the solution infused subcutaneously. The local effects of hypodermoclysis with or without hyaluronidase were investigated by using a randomized double-blind study in 12 dehydrated elderly patients. Five hundred millilitres of a 5% glucose saline solution was infused subcutaneously in 2 hours in each thigh, (A) with and (B) without 250 U of hyaluronidase. Circumference and temperature of each thigh were assessed before and after the infusion. Color was evaluated after the infusion. The gain in thigh circumference was less in the presence of hyaluronidase, but the other variables did not differ. The patients were thoroughly questioned about pain: no difference was noted between solutions A and B. We conclude that hyaluronidase adds no comfort that justifies its systematic use in the hypodermoclysis of glucose saline solutions.
脱水在老年患者中经常出现，皮下输液是肠外补液的一种替代方法。传统上，透明质酸酶会添加到皮下输注的溶液中。通过对12名脱水老年患者进行随机双盲研究，调查了使用或不使用透明质酸酶进行皮下输液的局部效果。在每条大腿上，于2小时内皮下输注500毫升5%葡萄糖盐水溶液，(A)组添加250单位透明质酸酶，(B)组不添加。在输注前后评估每条大腿的周长和温度。输注后评估皮肤颜色。在使用透明质酸酶的情况下，大腿周长的增加较少，但其他变量没有差异。对患者进行了关于疼痛的详细询问：A组和B组溶液之间没有差异。我们得出结论，透明质酸酶并不能带来足以证明其在葡萄糖盐水溶液皮下输液中常规使用合理性的舒适感。
