Scheeres Korine, Wensing Michel, Bleijenberg Gijs, Severens Johan L
Expert Centre Chronic Fatigue, Radboud University Nijmegen Medical Centre (4628), PO Box 9101, 6500 HB, The Netherlands.
BMC Health Serv Res. 2008 Aug 13;8:175. doi: 10.1186/1472-6963-8-175.
This study investigated the costs and outcomes of implementing cognitive behavior therapy (CBT) for chronic fatigue syndrome (CFS) in a mental health center (MHC). CBT is an evidence-based treatment for CFS that was scarcely available until now. To investigate the possibilities for wider implementation, a pilot implementation project was set up.
Costs and effects were evaluated in a non-controlled before- and after study with an eight months time-horizon. Both the costs of performing the treatments and the costs of implementing the treatment program were included in the analysis. The implementation interventions included: informing general practitioners (GPs) and CFS patients, training therapists, and instructing the MHC employees. Given the non-controlled design, cost outcome ratios (CORs) and their acceptability curves were analyzed. Analyses were done from a health care perspective and from a societal perspective. Bootstrap analyses were performed to estimate the uncertainty around the cost and outcome results.
125 CFS patients were included in the study. After treatment 37% had recovered from CFS and the mean gained QALY was 0.03. Costs of patients' health care and productivity losses had decreased significantly. From the societal perspective the implementation led to cost savings and to higher health states for patients, indicating dominancy. From the health care perspective the implementation revealed overall costs of 5.320 euros per recovered patient, with an acceptability curve showing a 100% probability for a positive COR at a willingness to pay threshold of 6.500 euros per recovered patient.
Implementing CBT for CFS in a MHC appeared to have a favorable cost outcome ratio (COR) from a societal perspective. From a health care perspective the COR depended on how much a recovered CFS patient is being valued. The strength of the evidence was limited by the non-controlled design. The outcomes of this study might facilitate health care providers when confronted with the decision whether or not to adopt CBT for CFS in their institution.
本研究调查了在心理健康中心(MHC)对慢性疲劳综合征(CFS)实施认知行为疗法(CBT)的成本和效果。CBT是一种针对CFS的循证治疗方法,到目前为止几乎难以获得。为了研究更广泛实施的可能性,设立了一个试点实施项目。
在一项为期八个月的非对照前后研究中评估成本和效果。分析中既包括进行治疗的成本,也包括实施治疗方案的成本。实施干预措施包括:通知全科医生(GPs)和CFS患者、培训治疗师以及指导MHC员工。鉴于非对照设计,分析了成本效果比(CORs)及其可接受性曲线,并从医疗保健角度和社会角度进行了分析。进行了自抽样分析以估计成本和效果结果的不确定性。
125名CFS患者纳入研究。治疗后,37%的患者从CFS中康复,平均获得的质量调整生命年(QALY)为0.03。患者的医疗保健成本和生产力损失显著下降。从社会角度看,实施该疗法可节省成本并使患者达到更高的健康状态,表明具有优势。从医疗保健角度看,每例康复患者的总体成本为5320欧元,可接受性曲线显示在每例康复患者支付意愿阈值为6500欧元时,COR为正值的概率为100%。
从社会角度看,在MHC对CFS实施CBT似乎具有良好的成本效果比(COR)。从医疗保健角度看,COR取决于对康复的CFS患者的重视程度。证据的力度受到非对照设计的限制。本研究结果可能有助于医疗保健提供者在决定其机构是否采用CBT治疗CFS时提供参考。