Jonsson J, Pegelow K O
Acta Pathol Microbiol Scand C. 1976 Oct;84C(5):353-64. doi: 10.1111/j.1699-0463.1976.tb00042.x.
The prevalence of antibodies against synthetic ACTH preparations and porcine gamma globulin was investigated in 29 asthmatic patients, in 28 rheumatic patients, and in 63 normal subjects of both sexes. Agglutinating antibodies were examined by a passive haemagglutination test and IgE antibodies by a radio-immuno assay. The incidence of agglutinating reactions against Synacthén and porcine gamma globulin was significantly higher in the asthmatic and rheumatic groups than in the group of normal subjects. Titres were generally low, attaining supposedly pathological levels (larger than or equal to 1/200) in about 10 per cent of the asthmatic patients and in 20-40 per cent of the rheumatic patients. In asthmatic patients, the incidence of ACTH specific IgE was higher than that in the normal group. This difference was not statistically significant in patients on routine treatment but it became satistically significant after ACTH booster treatment. In rheumatic patients the incidence of IgE antibodies against ACTH was insignificantly lower than that in the normal group. The incidence of agglutinating antibodies against vasopressin in asthmatic and rheumatic patients was also increased as compared with that in normal subjects and the titres were positively correlated to those against ACTH.
在29例哮喘患者、28例风湿患者以及63例男女正常受试者中，对合成促肾上腺皮质激素制剂和猪γ球蛋白抗体的流行情况进行了调查。通过被动血凝试验检测凝集抗体，通过放射免疫测定检测IgE抗体。哮喘组和风湿组中针对合成促肾上腺皮质激素和猪γ球蛋白的凝集反应发生率显著高于正常受试者组。滴度通常较低，约10%的哮喘患者和约20%-40%的风湿患者达到假定的病理水平（大于或等于1/200）。在哮喘患者中，促肾上腺皮质激素特异性IgE的发生率高于正常组。在接受常规治疗的患者中，这种差异无统计学意义，但在促肾上腺皮质激素加强治疗后具有统计学意义。在风湿患者中，针对促肾上腺皮质激素的IgE抗体发生率略低于正常组。与正常受试者相比，哮喘和风湿患者中抗血管加压素凝集抗体的发生率也有所增加，且滴度与抗促肾上腺皮质激素滴度呈正相关。
