Ueda Yutaka, Miyatake Takashi, Okazawa Mika, Kimura Toshihiro, Miyake Takahito, Fujiwara Kazuko, Yoshino Kiyoshi, Nakashima Ryuichi, Fujita Masami, Enomoto Takayuki
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Am J Clin Pathol. 2008 Sep;130(3):389-400. doi: 10.1309/ERR93AF840YYNDRQ.
We analyzed the clonality and human papillomavirus (HPV) infection status of concurrent glandular and squamous lesions and adenosquamous carcinomas of the uterine cervix to clarify their histogenesis. The glandular and squamous components were clonally different from each other in 7 informative concurrent lesions. HPV was episomal in 2 polyclonal glandular dysplasias (GDs). HPV was in a mixed integrated-episomal form in a monoclonal GD, an adenocarcinoma in situ, and an adenocarcinoma. Both tumor components were monoclonal in origin in 6 adenosquamous carcinomas, with identical patterns of X-chromosomal inactivation and types and physical status of HPV. These results imply that the concurrent glandular and squamous lesions are formed separately, whereas adenosquamous carcinoma is more likely to be a combination tumor of monoclonal origin, and that integration of HPV has an important role in the progression from polyclonal GD through monoclonal expansion to adenocarcinoma in situ and adenocarcinoma.
我们分析了子宫颈同时存在的腺性和鳞状病变以及腺鳞癌的克隆性和人乳头瘤病毒（HPV）感染状态，以阐明它们的组织发生情况。在7例有信息价值的同时性病变中，腺性和鳞状成分彼此克隆性不同。在2例多克隆性腺发育异常（GD）中，HPV呈游离状态。在1例单克隆性GD、1例原位腺癌和1例腺癌中，HPV呈整合型与游离型混合状态。在6例腺鳞癌中，两种肿瘤成分均起源于单克隆，具有相同的X染色体失活模式以及相同类型和物理状态的HPV。这些结果表明，同时存在的腺性和鳞状病变是分别形成的，而腺鳞癌更可能是起源于单克隆的混合性肿瘤，并且HPV的整合在从多克隆性GD通过单克隆扩增发展为原位腺癌和腺癌的过程中起重要作用。
