Mizuuchi A
Department of Surgery, Tokyo Police Hospital.
Nihon Ronen Igakkai Zasshi. 1991 Mar;28(2):210-6. doi: 10.3143/geriatrics.28.210.
To elucidate morphological change of alveoli in compensatory lung growth, left pneumonectomy was performed on male 4 weeks-old rats (Fischer-344) and light microscopic morphometry, scanning electron microscopic study and histochemistry using anti-bromodeoxyuridine were made. The wet lung weight and lung volume of the residual lungs in the pneumonectomized rats reached the same as those of sham operated rats at one and two weeks after the operation, respectively. From the data concerning the mean linear intercept in the cardiac lobe of the pneumonectomized rats, alveoli of two different sizes were observed, suggesting that the compensatory lung growth in the alveoli may take two steps or at least two different sizes of alveoli may exist mixed together. The data of histochemistry suggest that in pneumonectomized rats the alveoli beneath the pleura (less than 2 mm) included an increased number of S phase cells compared with those of deeper areas. From these morphological changes in the lungs of the pneumonectomized rats it is possible to suggest a hypothesis that stretch stimulation is the first trigger in compensatory lung growth.
为阐明代偿性肺生长过程中肺泡的形态变化，对4周龄雄性大鼠（Fischer-344）实施左肺切除术，并进行了光镜形态计量学、扫描电子显微镜研究以及使用抗溴脱氧尿苷的组织化学分析。肺切除术后1周和2周时，肺切除大鼠残肺的湿肺重量和肺体积分别达到假手术大鼠的水平。根据肺切除大鼠心叶平均线性截距的数据，观察到两种不同大小的肺泡，提示肺泡的代偿性肺生长可能分两个阶段进行，或者至少存在两种不同大小的肺泡混合在一起。组织化学数据表明，与更深区域相比，肺切除大鼠胸膜下（小于2毫米）的肺泡中S期细胞数量增加。从肺切除大鼠肺部的这些形态变化可以提出一个假说，即牵张刺激是代偿性肺生长的首要触发因素。
