Sosenko I R, Frank L
Am J Physiol. 1985 Jul;249(1 Pt 2):R125-32. doi: 10.1152/ajpregu.1985.249.1.R125.
Adult rats treated with endotoxin, like untreated neonatal rats, are resistant to O2 toxicity and manifest very similar lung biochemical responses. We hypothesized that endotoxin might also alter the adult pneumonectomy response to resemble the accelerated response of younger animals. Adult and 19-day rats underwent pneumonectomy, followed in 24 h by endotoxin or saline injection. Pneumonectomized rats, shams, and controls were killed 72 h after surgery for lung biochemistry and morphometry. Compared with adult saline-pneumonectomized rats, adult endotoxin-pneumonectomized rats, adult endotoxin-pneumonectomized rats demonstrated a significantly greater growth response and a lung biochemical response pattern (increased RNA, markedly increased RNA/DNA) similar to 19-day rats. Morphologically, endotoxin-pneumonectomized rats showed a different pattern of lung regrowth (significantly larger air spaces). Saline pressure-volume curves were not different between the two groups. We conclude that endotoxin administration to pneumonectomized adult rats resulted in accelerated lung regrowth, a lung biochemical response pattern similar to 19-day rats, but a paradoxical morphological pattern resembling more closely that of the adult than the neonatal animal.
用内毒素处理的成年大鼠，与未处理的新生大鼠一样，对氧毒性具有抗性，并表现出非常相似的肺生化反应。我们推测内毒素也可能改变成年大鼠肺切除术后的反应，使其类似于年幼动物的加速反应。成年大鼠和19日龄大鼠接受肺切除术，术后24小时注射内毒素或生理盐水。肺切除术后的大鼠、假手术组和对照组在术后72小时处死，进行肺生化和形态学测量。与成年生理盐水肺切除术后大鼠相比，成年内毒素肺切除术后大鼠表现出显著更大的生长反应和类似于19日龄大鼠的肺生化反应模式（RNA增加，RNA/DNA显著增加）。形态学上，内毒素肺切除术后大鼠表现出不同的肺再生模式（气腔显著增大）。两组之间的生理盐水压力-容积曲线没有差异。我们得出结论，给成年肺切除术后大鼠注射内毒素会导致肺再生加速，肺生化反应模式类似于19日龄大鼠，但形态学模式与成年动物更为相似，而非新生动物，这是一个矛盾的现象。
