A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.
作者信息
Andreeva Antonina, Tidow Henning
机构信息
MRC Centre for Protein Engineering, Cambridge, UK.
出版信息
Bioinformatics. 2008 Oct 15;24(20):2277-80. doi: 10.1093/bioinformatics/btn431. Epub 2008 Aug 14.
Abstract
We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.
摘要
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