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细胞脂肪与血小板凝胶混合用于进行性半侧面部萎缩。

Use of cell fat mixed with platelet gel in progressive hemifacial atrophy.

作者信息

Cervelli V, Gentile P

机构信息

Department of Plastic and Reconstructive Surgery Policlinico Casilino, University Tor Vergata, Rome, Italy.

出版信息

Aesthetic Plast Surg. 2009 Jan;33(1):22-7. doi: 10.1007/s00266-008-9223-x. Epub 2008 Aug 14.

DOI:10.1007/s00266-008-9223-x
PMID:18704559
Abstract

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome, is an uncommon degenerative and poorly understood condition. It is characterized by a slow and progressive atrophy affecting one side of the face. The incidence and cause of this alteration are unknown, and the pathogenesis of the syndrome is not clear. Some authors attribute the atrophy of the subcutaneous system to an alteration of the sympathetic system. Others attribute it to an alteration of the nervous system at the encephalic level or to an interstitial neuritis of the trigeminal nerve. The most common complications that appear in association with this disorder are trigeminal neuritis, facial disorders, and epilepsy. The latter is the most frequent complication of the central nervous system. Characteristically, the atrophy progresses slowly for several years and soon becomes stable. After stabilization of the disease, plastic surgery of autogenous fat grafts can be performed. This study aimed through the presentation of clinical cases to suggest a therapeutic plan comprised of two sequential treatments: aquisition of platelet gel from a small volume of blood (9 ml) followed by the Coleman technique for reconstructing the three-dimensional projection of the face contour, restoring the superficial density of the facial tissues. The results obtained prove the efficacy of these two treatments combined, and the satisfaction of the patient confirms the quality of the results.

摘要

进行性半侧面部萎缩,也称为帕里-罗姆伯格综合征,是一种罕见的、了解甚少的退行性疾病。其特征是一侧面部出现缓慢进行性萎缩。这种改变的发病率和病因尚不清楚,该综合征的发病机制也不明确。一些作者将皮下系统的萎缩归因于交感神经系统的改变。另一些人则将其归因于脑水平的神经系统改变或三叉神经的间质性神经炎。与这种疾病相关出现的最常见并发症是三叉神经炎、面部疾病和癫痫。后者是中枢神经系统最常见的并发症。典型的情况是,萎缩会缓慢进展数年,然后很快趋于稳定。疾病稳定后,可以进行自体脂肪移植的整形手术。本研究旨在通过临床病例展示,提出一个由两种序贯治疗组成的治疗方案:从小体积血液(9毫升)中获取血小板凝胶,然后采用科尔曼技术重建面部轮廓的三维投影,恢复面部组织的表面密度。所获得的结果证明了这两种治疗方法联合使用的有效性,患者的满意度也证实了结果的质量。

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