Yang Shih-Chieh, Fu Tsai-Sheng, Chen Lih-Huei, Chen Wen-Jer, Tu Yuan-Kun
Department of Orthopedic Surgery, E-DA Hospital, I-Shou University, Kaohsiung , Taiwan.
Clin Orthop Relat Res. 2008 Dec;466(12):3086-92. doi: 10.1007/s11999-008-0441-y. Epub 2008 Aug 13.
Identifying offending pathogens is crucial for appropriate antibiotic administration for infectious spondylitis. Although computed tomography (CT)-guided biopsy for bacteriologic diagnosis is a standard procedure, it has a variable success rate. Some reports claim percutaneous endoscopic discectomy and drainage offer a sufficient amount of tissue for microbiologic examination and easy application. We therefore compared the diagnostic value of CT guidance with that of endoscope guidance in 52 patients with suspected infectious spondylitis. Twenty patients underwent percutaneous endoscopic discectomy and drainage by an orthopaedic surgeon and the other 32 patients underwent CT-guided biopsies by a radiologist. Patients were followed a minimum of 12 months after treatment. Culture results of the biopsy specimens were recorded. Causative bacteria were identified more frequently with percutaneous endoscopy than in CT-guided biopsy (18 of 20 [90%] versus 15 of 32 [47%]). We observed no biopsy-related complications or side effects in either group. The data suggest percutaneous endoscopic discectomy and drainage yield higher bacterial recovery rates than CT-guided spinal biopsy.
Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
对于感染性脊柱炎的恰当抗生素治疗而言,识别致病病原体至关重要。尽管计算机断层扫描(CT)引导下的活检用于细菌学诊断是一种标准程序,但其成功率不一。一些报告称经皮内镜下椎间盘切除术及引流可为微生物学检查提供足够的组织量且应用简便。因此,我们比较了CT引导与内镜引导对52例疑似感染性脊柱炎患者的诊断价值。20例患者由骨科医生进行经皮内镜下椎间盘切除术及引流,另外32例患者由放射科医生进行CT引导下活检。治疗后对患者进行至少12个月的随访。记录活检标本的培养结果。经皮内镜检查比CT引导下活检更频繁地鉴定出致病细菌(20例中的18例[90%]对32例中的15例[47%])。我们在两组中均未观察到与活检相关的并发症或副作用。数据表明,经皮内镜下椎间盘切除术及引流比CT引导下脊柱活检有更高的细菌检出率。
III级,治疗性研究。有关证据水平的完整描述,请参见作者指南。