Matute Carlos
CIBERNED, Departamento de Neurociencias, Universidad del País Vasco, 48940-Leioa, and Neurotek-UPV/EHU, Parque Tecnológico de Bizkaia, 48170 Zamudio, Spain.
Mol Neurobiol. 2008 Oct;38(2):123-8. doi: 10.1007/s12035-008-8028-x. Epub 2008 Aug 14.
Intense ATP signaling through P2X7 purinergic receptors can lead to excitotoxicity, a feature which initiates neuronal demise in experimental paradigms relevant to ischemia and to traumatic injury. In addition, recent data provide evidence that oligodendrocytes also express P2X7 receptors that are activated under experimental pathological conditions involving white matter demise. Thus, this receptor subtype is a promising target for the development of new drugs to prevent white matter damage in acute and chronic diseases.
通过P2X7嘌呤能受体的强烈ATP信号传导可导致兴奋性毒性，这一特征在与缺血和创伤性损伤相关的实验范式中引发神经元死亡。此外，最近的数据表明，少突胶质细胞也表达P2X7受体，这些受体在涉及白质死亡的实验病理条件下被激活。因此，这种受体亚型是开发预防急慢性疾病中白质损伤新药的一个有前景的靶点。
