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分层皮片移植在糖尿病足溃疡治疗中的应用

Split-skin graft in the management of diabetic foot ulcers.

作者信息

Mahmoud S M, Mohamed A A, Mahdi S E I, Ahmed M E

机构信息

Soba University Hospital, Khartoum, Sudan.

出版信息

J Wound Care. 2008 Jul;17(7):303-6. doi: 10.12968/jowc.2008.17.7.30522.

Abstract

OBJECTIVE

To compare the effects of split-thickness skin grafts versus a conservative wound dressing on the healing times of diabetic foot ulcers and the length of hospital stay.

METHOD

In this prospective case-controlled study, 50 patients consented to skin grafting (graft group) and 50 preferred to be managed by conservative dressings (control group). Wound management in both groups was standardised with regard to the dressing materials (which comprised a multilayer dressing including paraffin gauze and diluted povidone-iodine soaked gauze), wound care and surgeon involvement. Graft take, ulcer recurrence rate and donor-site morbidity were assessed. Healing times and the length of hospital stay were compared between the two groups.

RESULTS

A 100% skin graft take was recorded in 84% of the patients on the fifth postoperative day and in 62% on weeks 3 and 8. All patients in the graft group healed completely, but 8% had an ulcer recurrence and 4% a superficial infection within the following year. The mean healing time and mean length of hospital stay were significantly less in the graft group compared with the control group (p<0.001), reflecting results of similar studies.

CONCLUSION

Split-skin grafting is an effective method of managing diabetic foot ulcers as, compared with the conservative dressings used in this study, it reduced healing times and the length of hospital stay, while donor-site morbidity was minimal.

摘要

目的

比较中厚皮片移植与保守伤口敷料对糖尿病足溃疡愈合时间及住院时间的影响。

方法

在这项前瞻性病例对照研究中,50例患者同意接受皮肤移植(移植组),50例患者更倾向于采用保守敷料治疗(对照组)。两组的伤口处理在敷料材料(包括多层敷料,其中有石蜡纱布和稀释聚维酮碘浸泡纱布)、伤口护理及外科医生参与方面进行了标准化。评估植皮成功率、溃疡复发率及供皮区发病率。比较两组的愈合时间及住院时间。

结果

术后第5天,84%的患者植皮完全成功,第3周和第8周时为62%。移植组所有患者均完全愈合,但在接下来的一年中,8%的患者溃疡复发,4%的患者发生浅表感染。与对照组相比,移植组的平均愈合时间和平均住院时间显著缩短(p<0.001),这与类似研究结果相符。

结论

与本研究中使用的保守敷料相比,中厚皮片移植是治疗糖尿病足溃疡的一种有效方法,它可缩短愈合时间和住院时间,同时供皮区发病率极低。

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