Ahmad I, Akhtar S, Masoodi Z
J Wound Care. 2012 Sep;21(9):442-4, 446-7. doi: 10.12968/jowc.2012.21.9.442.
To assess the efficacy of radical debridement and skin grafting in treating diabetic foot ulceration, compared with conservative wound treatment.
The medical notes for 30 patients who underwent skin grafting for diabetic foot ulceration (graft group) were retrospectively analysed and matched, according to age, gender, ankle brachial pressure index (ABPI) and comorbidities, with 30 other patients, who were treated conservatively (control group). Patients in the graft group underwent early, radical debridement to prepare the wound bed for grafting. Graft take, rate of ulcer recurrence and donor-site morbidity were assessed. Healing times and the length of hospital stays were compared between the two groups.
A 100% skin graft take was recorded in 80% of the patients on day 4, postoperatively. Ninety-three per cent of patients in the graft group completely healed, with 2 patients (6.7%) experiencing ulcer recurrence within the following 6 months. Ulcer recurrence could be due to early, non-guarded ambulation. Mean healing time and hospital stay were significantly lower in the graft group compared with the control group (4.0 ± 1.5 weeks vs 10.0 ± 1.0 weeks; p < 0.001). Mean healing time in smokers was slightly greater than non-smokers.
Skin graft is an effective method of managing diabetic foot ulcers compared with dressings. It reduced healing times and hospital stay with minimum donor-site morbidity.
There were no external sources of funding for this study. The authors have no conflicts of interest to declare.
评估根治性清创术和皮肤移植术治疗糖尿病足溃疡的疗效,并与保守伤口治疗进行比较。
回顾性分析30例行糖尿病足溃疡皮肤移植术患者(移植组)的病历,并根据年龄、性别、踝肱压力指数(ABPI)和合并症,与另外30例接受保守治疗的患者(对照组)进行匹配。移植组患者接受早期根治性清创术,为移植准备伤口床。评估移植成功率、溃疡复发率和供区发病率。比较两组的愈合时间和住院时间。
术后第4天,80%的患者皮肤移植成功率达100%。移植组93%的患者完全愈合,2例患者(6.7%)在接下来的6个月内出现溃疡复发。溃疡复发可能是由于早期无保护的行走。与对照组相比,移植组的平均愈合时间和住院时间显著缩短(4.0±1.5周对10.0±1.0周;p<0.001)。吸烟者的平均愈合时间略长于非吸烟者。
与敷料相比,皮肤移植是治疗糖尿病足溃疡的有效方法。它减少了愈合时间和住院时间,供区发病率最低。
本研究没有外部资金来源。作者没有利益冲突需要声明。