Tanaka Akira, Ishikawa Shinpei, Okuno Kiyotaka, Shiozaki Hitoshi
Surgery, Sakai Hospital, School of Medicine, Kinki University, Sakai, Osaka 590-0132, Japan.
Hepatogastroenterology. 2008 May-Jun;55(84):963-6.
BACKGROUND/AIMS: For esophageal cancer, the incidence of lymphatic, local, and hematogenous recurrence is high, and prognosis is poor. This study examined utility of chemoradiotherapy for neural invasion, a risk factor for local recurrence, and a poor prognosis factor.
Neural invasion was studied histochemically in 183 patients with resected advanced esophageal squamous cell carcinoma, of T2 or greater depth of wall invasion.
Neural invasion positivity occurred in 78 of 183 (46.2%) patients, 11 of 21 (52.4%) of the preoperative radiotherapy alone group, and 5 of 22 (22.7%) in the preoperative chemoradiotherapy group (p<0.05). The local recurrence rate overall was 15.0% in the preoperative radiotherapy alone group compared to 5.9% in the chemoradiotherapy group.
Chemoradiotherapy is effective for neural invasion in comparison with radiotherapy alone.
背景/目的：食管癌的淋巴、局部和血行复发率高，预后较差。本研究探讨了放化疗对神经侵犯（局部复发的危险因素和预后不良因素）的作用。
对183例切除的进展期食管鳞状细胞癌患者（肿瘤侵犯深度达T2或更深）进行神经侵犯的组织化学研究。
183例患者中有78例（46.2%）神经侵犯呈阳性，单纯术前放疗组21例中有11例（52.4%），术前放化疗组22例中有5例（22.7%）（p<0.05）。单纯术前放疗组的总体局部复发率为15.0%，而放化疗组为5.9%。
与单纯放疗相比，放化疗对神经侵犯有效。
