Miyakuni Yasuka, Matsumoto Toshiharu, Arakawa Atsushi, Sonoue Hiroshi, Suzuki Chikako, Takeda Satoru
Department of Obstetrics and Gynecology, Juntendo University, School of Medicine, Tokyo, Japan.
Pathol Int. 2008 Aug;58(8):471-6. doi: 10.1111/j.1440-1827.2008.02258.x.
In endometrioid adenocarcinoma of the uterine corpus, nodal metastasis is related to prognosis. D2-40 immunostaining has recently been used to detect lymphatic invasion, but a study of D2-40 immunostaining for endometrioid adenocarcinoma of the uterine corpus has not been published. Therefore, as a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus, the detection of lymphatic invasion on D2-40 immunostaining and lymphovascular invasion on HE stain was compared. A total of 104 cases of invasive endometrioid adenocarcinoma of the uterine corpus, in which the tumor was located in the uterus, were examined on immunohistochemistry using D2-40. In 20 cases there was lymphatic invasion according to D2-40 immunostaining, and the lymphatic invasion was well detected on D2-40 immunostaining. Nodal metastasis was present in 11 cases. Both lymphatic invasion on D2-40 immunostaining and lymphovascular invasion on HE stain were statistically correlated with nodal metastasis, but the evaluation of lymphatic invasion on D2-40 immunostaining was more accurate than detection of lymphovascular invasion using HE stain, in the current and previous studies, for the prediction of nodal metastasis. In conclusion, lymphatic invasion demonstrated on D2-40 immunostaining is very useful as a predictor for nodal metastasis in endometrioid adenocarcinoma of uterine corpus.
在子宫体子宫内膜样腺癌中，淋巴结转移与预后相关。D2-40免疫染色最近被用于检测淋巴血管浸润，但关于子宫体子宫内膜样腺癌的D2-40免疫染色研究尚未发表。因此，作为子宫体子宫内膜样腺癌淋巴结转移的预测指标，比较了D2-40免疫染色检测淋巴血管浸润和苏木精-伊红（HE）染色检测淋巴管浸润的情况。对总共104例肿瘤位于子宫的子宫体浸润性子宫内膜样腺癌病例进行了D2-40免疫组织化学检查。根据D2-40免疫染色，20例存在淋巴血管浸润，且D2-40免疫染色能很好地检测到淋巴血管浸润。11例存在淋巴结转移。D2-40免疫染色检测的淋巴血管浸润和HE染色检测的淋巴管浸润均与淋巴结转移存在统计学相关性，但在当前及既往研究中，对于预测淋巴结转移，D2-40免疫染色评估淋巴血管浸润比HE染色检测淋巴管浸润更准确。总之，D2-40免疫染色显示的淋巴血管浸润作为子宫体子宫内膜样腺癌淋巴结转移的预测指标非常有用。
