Kusafuka Kimihide, Ueno Takao, Kurihara Kinue, Murata Tsubasa, Yurikusa Takashi, Henmi Hitoshi, Akane Mitsunori, Ota Yojiro, Kameya Toru
Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
Pathol Int. 2008 Aug;58(8):524-8. doi: 10.1111/j.1440-1827.2008.02267.x.
Cystadenoma is a relatively rare benign epithelial tumor of the salivary glands, and described herein is an additional case. A 51-year-old Japanese man had noticed a mass of the left hard palate 25 years previously. Macroscopically, the resected specimen was a multicystic lesion. Histologically, the tumor was composed of bilayered columnar epithelium with cystic change and partial solid growth of glandular structures with clear cells. The tumor cells had mild cellular atypia, but the tumor lacked papillary growth and a fibrous capsule. Immunohistochemistry was positive for cytokeratins, epithelial membrane antigen, MUC1, MUC4 and MUC6, but negative for myoepithelial markers, MUC2, MUC5AC and MUC5B. Such MUC expression patterns suggested that cystadenoma occurs from excretory ducts.
囊腺瘤是一种相对罕见的唾液腺良性上皮性肿瘤，本文描述了另外一例病例。一名51岁的日本男性25年前发现左侧硬腭有肿物。大体上，切除的标本为多囊性病变。组织学上，肿瘤由双层柱状上皮构成，伴有囊性变以及腺结构的部分实性生长，其中可见透明细胞。肿瘤细胞有轻度细胞异型性，但肿瘤无乳头状生长且缺乏纤维性包膜。免疫组化显示细胞角蛋白、上皮膜抗原、MUC1、MUC4和MUC6呈阳性，但肌上皮标志物、MUC2、MUC5AC和MUC5B呈阴性。这种MUC表达模式提示囊腺瘤起源于排泄管。
