Sugino Atsushi, Ohtsuki Chikara, Tsuru Kanji, Hayakawa Satoshi, Nakano Takayoshi, Okazaki Yoshimitsu, Osaka Akiyoshi
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya-shi, Aichi 464-8603, Japan.
Acta Biomater. 2009 Jan;5(1):298-304. doi: 10.1016/j.actbio.2008.07.014. Epub 2008 Jul 30.
Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects. The aim of this study was to investigate the effects of thermal oxidation on apatite formation in macro-grooves on Ti-15Zr-4Ta-4Nb. Thermal oxidation at 500 and 600 degrees C in air led to modification of the Ti-15Zr-4Ta-4Nb surface to rutile phase titanium oxide. Ti-15Zr-4Ta-4Nb thermally oxidized at 500 degrees C in air showed no changes in metallographic structure, but not at 600 degrees C. After soaking in a simulated body fluid for 7days, the formation of apatite could be observed on the internal surfaces of macro-grooves 500mum deep and wide on Ti-15Zr-4Ta-4Nb thermally oxidized at 500 and 600 degrees C in air. These results indicate the potential for osteoconductivity of Ti-15Zr-4Ta-4Nb without changing its metallographic structure, by fabricating only the macro-grooves, i.e., spatial design, and by performing thermal oxidation at 500 degrees C.
钛及其合金表面的磷灰石形成对于植入骨缺损时诱导骨传导性是有效的。本研究的目的是研究热氧化对Ti-15Zr-4Ta-4Nb宏观凹槽中磷灰石形成的影响。在空气中500和600摄氏度下进行热氧化导致Ti-15Zr-4Ta-4Nb表面改性为金红石相氧化钛。在空气中500摄氏度下热氧化的Ti-15Zr-4Ta-4Nb金相结构无变化，但在600摄氏度下有变化。在模拟体液中浸泡7天后，在空气中500和600摄氏度下热氧化的Ti-15Zr-4Ta-4Nb上500微米深且宽的宏观凹槽内表面可观察到磷灰石的形成。这些结果表明，通过仅制造宏观凹槽（即空间设计）并在500摄氏度下进行热氧化，Ti-15Zr-4Ta-4Nb在不改变其金相结构的情况下具有骨传导性的潜力。
