Chen Xiaobo, Nouri Alireza, Li Yuncang, Lin Jianguo, Hodgson Peter D, Wen Cui'e
Centre for Material and Fibre Innovation, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3217, Australia.
Biotechnol Bioeng. 2008 Oct 1;101(2):378-87. doi: 10.1002/bit.21900.
Some of the critical properties for a successful orthopedic or dental implant material are its biocompatibility and bioactivity. Pure titanium (Ti) and zirconium (Zr) are widely accepted as biocompatible metals, due to their non-toxicity. While the bioactivity of Ti and some Ti alloys has been extensively investigated, there is still insufficient data for Zr and titanium-zirconium (TiZr) alloys. In the present study, the bioactivity, that is, the apatite forming ability on the alkali and heat treated surfaces of Ti, Zr, and TiZr alloy in simulated body fluid (SBF), was studied. In particular, the effect of the surface roughness characteristics on the bioactivity was evaluated for the first time. The results indicate that the pretreated Ti, Zr and TiZr alloy could form apatite coating on their surfaces. It should be noted that the surface roughness also critically affected the bioactivity of these pretreated metallic samples. A surface morphology with an average roughness of approximately 0.6 microm led to the fastest apatite formation on the metal surfaces. This apatite layer on the metal surface is expected to bond to the surrounding bones directly after implantation.
一种成功的骨科或牙科植入材料的一些关键特性是其生物相容性和生物活性。纯钛（Ti）和锆（Zr）因其无毒而被广泛认为是生物相容性金属。虽然钛及一些钛合金的生物活性已得到广泛研究，但关于锆及钛锆（TiZr）合金的数据仍然不足。在本研究中，研究了钛、锆和钛锆合金在模拟体液（SBF）中经过碱处理和热处理的表面上的生物活性，即磷灰石形成能力。特别是，首次评估了表面粗糙度特性对生物活性的影响。结果表明，预处理后的钛、锆和钛锆合金能够在其表面形成磷灰石涂层。应当指出的是，表面粗糙度也对这些预处理金属样品的生物活性有至关重要的影响。平均粗糙度约为0.6微米的表面形态导致金属表面磷灰石形成最快。这种金属表面的磷灰石层预计在植入后能直接与周围骨骼结合。
