Jansen Jacobus F A, Lemmens Evi M P, Strijkers Gustav J, Prompers Jeanine J, Schijns Olaf E M G, Kooi M Eline, Beuls Emile A M, Nicolay Klaas, Backes Walter H, Hoogland Govert
Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands.
Neurobiol Dis. 2008 Nov;32(2):293-301. doi: 10.1016/j.nbd.2008.07.010. Epub 2008 Jul 27.
Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations.
已知实验性热性惊厥（FS）会促进边缘系统的过度兴奋，并增加最终患颞叶癫痫（TLE）的风险。体内连续MRI可能会提供伴随的微观结构和代谢变化的早期标志物。通过热疗在9日龄大鼠中诱导FS。在FS大鼠和年龄匹配的对照大鼠中，分别于24小时和8周后应用定量多模态MRI，包括海马体积测量和质子光谱分析，以及脑T2弛豫测量和扩散张量成像（DTI）。在9周时进行组织学检查。海马T2弛豫时间升高似乎是短暂的。杏仁核中检测到的DTI异常持续长达8周。海马体积未受影响。组织学显示海马纤维密度和各向异性增加，杏仁核神经元表面积减少。定量连续MRI能够检测到反映微观结构改变的短暂性、最重要的是长期的FS诱导变化。
