Lim Hyunjung Jade, Dey S K
Department of Biomedical Science & Technology, Research Center for Drugs, IBST, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701 Korea.
Exp Cell Res. 2009 Feb 15;315(4):619-26. doi: 10.1016/j.yexcr.2008.07.025. Epub 2008 Aug 3.
An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and membrane-bound molecules for more immediate interactions. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) was identified as an early messenger of implantation which uses both modes of communication. In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process.
一个具有着床能力的囊胚，在附着于子宫壁前数小时，会向周围的子宫细胞传递信号，反之亦然，从而启动双向相互作用。这种早熟对话的语言是多样的，利用分泌分子进行远程相互作用，利用膜结合分子进行更直接的相互作用。肝素结合表皮生长因子样生长因子（HB-EGF）被确定为着床的早期信使，它利用这两种通讯方式。在这篇综述中，我们讨论了HB-EGF的印记，即它最初是如何被确定为着床介质的，以及它在这个过程中是如何启动胚胎-子宫相互作用的。
