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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Khoo U S, Chan K Y, Chan V S, Ching J C Y, Yam L, Chu C M, Lai S T, Wong T Y, Tam P, Yip S P, Leung G M, Lin C L, Peiris J S M

Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Hong Kong Med J. 2008 Aug;14 Suppl 4:31-5.

A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.

一项涉及1200多名受试者的基因风险关联研究表明，L-SIGN串联重复纯合子个体对SARS感染的易感性较低。2. 体外结合研究支持了这一点，该研究表明，与杂合子相比，纯合L-SIGN对SARS冠状病毒（SARS-CoV）具有更高的结合能力，且蛋白酶体依赖性病毒降解更高。相比之下，纯合L-SIGN对HIV1-gp120的结合能力较低。3. 对炎症反应基因（即TNF-α、INF-α、INF-β、INF-γ、IL1-α、IL1-β、IL-4、IL-6和iNOS）的单核苷酸多态性进行的基因关联研究未能显示出与SARS临床结果或易感性有显著关联。

Khoo U S, Chan K Y, Chan V S, Ching J C Y, Yam L, Chu C M, Lai S T, Wong T Y, Tam P, Yip S P, Leung G M, Lin C L, Peiris J S M

Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Hong Kong Med J. 2008 Aug;14 Suppl 4:31-5.

A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.

一项涉及1200多名受试者的基因风险关联研究表明，L-SIGN串联重复纯合子个体对SARS感染的易感性较低。2. 体外结合研究支持了这一点，该研究表明，与杂合子相比，纯合L-SIGN对SARS冠状病毒（SARS-CoV）具有更高的结合能力，且蛋白酶体依赖性病毒降解更高。相比之下，纯合L-SIGN对HIV1-gp120的结合能力较低。3. 对炎症反应基因（即TNF-α、INF-α、INF-β、INF-γ、IL1-α、IL1-β、IL-4、IL-6和iNOS）的单核苷酸多态性进行的基因关联研究未能显示出与SARS临床结果或易感性有显著关联。