Juhn S K, Tolan C J, Antonelli P J, Giebink G S, Goycoolea M V
Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis.
Otolaryngol Clin North Am. 1991 Aug;24(4):813-27.
Animal models have been instrumental in investigating otitis media. Experimental models have allowed for focused research on how such factors as eustachian tube dysfunction and microbial infection contribute to the pathogenesis of otitis media. Antibacterial therapy and immunologic prophylaxis have been developed using these models. Current research is aimed at generating an objective index of middle ear inflammation for guiding patient management.
动物模型在中耳炎研究中发挥了重要作用。实验模型使得人们能够集中研究诸如咽鼓管功能障碍和微生物感染等因素如何导致中耳炎的发病机制。利用这些模型开发了抗菌疗法和免疫预防措施。目前的研究旨在生成一个中耳炎症的客观指标，以指导患者的治疗。
