Fulton R W, Rosenquist B D
Am J Vet Res. 1976 Dec;37(12):1493-5.
The effect of hydrocortisone on bovine interferon production in vitro was studied. Infectious bovine rhinotracheitis virus was used as an inducer. Interferon was assayed by the plaque-reduction method in bovine fetal kidney cultures, using vesicular stomatitis virus as challenge virus. Hydrocortisone decreased interferon production in bovine fetal spleen and peripheral blood leukocyte cultures. Hydrocortisone did not decrease interferon production by bovine alveolar macrophages, in 1 experiment. Properties of viral inhibitors were those of interferon.
研究了氢化可的松对体外培养的牛干扰素产生的影响。使用传染性牛鼻气管炎病毒作为诱导剂。采用蚀斑减少法，以水疱性口炎病毒作为攻击病毒，在牛胎肾培养物中检测干扰素。氢化可的松降低了牛胎脾和外周血白细胞培养物中的干扰素产生。在1项实验中，氢化可的松未降低牛肺泡巨噬细胞产生的干扰素。病毒抑制剂的特性与干扰素的特性相同。
