Durak H, Bekdik C F, Ulutuncel N
Department of Nuclear Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Nuklearmedizin. 1991 Jun;30(3):100-3.
The regional clearance of 133Xe from the lungs after intravenous administration as well as following rebreathing was assessed in 7 normals and 18 patients with various lung disorders. Each lung was divided into three zones as upper, middle and lower. Regional ventilation (V) and regional perfusion (P) were determined using the area under the first peak at the beginning of the ventilation study and the area under the peak after intravenous administration, respectively. Slopes were calculated using the first exponential of the wash-out curve. Absolute slope values of the wash-out curves after perfusion (Pwo) and ventilation (Vwo) were expressed as a percentage of the total for each lung. Correlation coefficients between V and Vwo, V and Pwo, P and Pwo were .695, .584 and .882 in normals and .610, .461 and .685 in patients, respectively. It is concluded that Pwo is influenced by both perfusion and ventilation; it may reflect the fractional contribution to the gas exchange and can be used in the prediction of residual lung function after lung resection.
对7名正常人和18名患有各种肺部疾病的患者，评估了静脉注射后以及再呼吸后133Xe从肺部的区域清除情况。每个肺被分为上、中、下三个区域。分别使用通气研究开始时第一个峰值下的面积和静脉注射后峰值下的面积来确定区域通气（V）和区域灌注（P）。使用洗脱曲线的第一个指数来计算斜率。灌注（Pwo）和通气（Vwo）后洗脱曲线的绝对斜率值表示为每个肺总量的百分比。正常人和患者中V与Vwo、V与Pwo、P与Pwo之间的相关系数分别为0.695、0.584和0.882以及0.610、0.461和0.685。结论是，Pwo受灌注和通气两者影响；它可能反映对气体交换的分数贡献，并可用于预测肺切除术后的残余肺功能。
