用于持续释放可卡因的硅胶丸：与持续释放苯丙胺的比较。

A silicone pellet for continuous cocaine: comparison with continuous amphetamine.

作者信息

Lipton J, Zeigler S, Wilkins J, Ellison G

机构信息

Department of Psychology, University of California, Los Angeles, CA 90024.

出版信息

Pharmacol Biochem Behav. 1991 Apr;38(4):927-30. doi: 10.1016/0091-3057(91)90266-5.

DOI:10.1016/0091-3057(91)90266-5

PMID:1871207

Abstract

An inexpensive silicone pellet is described for the continuous administration of cocaine for up to 5 days. Rats implanted with this pellet show minimal skin irritation and go through distinct behavioral stages, with an initial period of hyperactivity followed by motor stereotypies. Then, at 3-4 days after implantation, a variety of hallucinogen-like ("late-stage") behaviors appear, including limb flicks, sudden startle responses, and repetitive mid-air grasping movements. Compared to continuous d-amphetamine, continuous cocaine induces decreased motor stereotypies but heightened "late-stage" behaviors.

摘要

描述了一种用于连续5天给予可卡因的廉价硅胶丸剂。植入这种丸剂的大鼠表现出最小的皮肤刺激，并经历不同的行为阶段，最初是多动期，随后是运动刻板行为。然后，在植入后3-4天，出现各种类似致幻剂的（“后期”）行为，包括肢体轻弹、突然惊吓反应和重复的空中抓握动作。与连续给予右旋苯丙胺相比，连续给予可卡因会导致运动刻板行为减少，但“后期”行为增强。