Huberman H S, Eison M S, Bryan K S, Ellison G
Eur J Pharmacol. 1977 Oct 1;45(3):237-42. doi: 10.1016/0014-2999(77)90004-8.
A slow release amphetamine pellet consisting of a silicone capsule containing d-amphetamine base in polyethylene glycol is described. When implanted s.c. in rats this pellet produces brain levels initially comparable to an i.p. dose of 2 mg/kg of d-amphetamine sulfate; these levels gradually fall but appreciable amphetamine remains present in the brain for over 10 days. Rats implanted with these pellets exhibit sustained motor stereotypies and constant hyperactivity in stabilimeters for 2-3 days. Four days after implantation activity declines to near control levels even though amphetamine is still present in the brain. During this later stage rats show exaggerated startle responses and resist handling. This pellet is a unique tool for the study of the behavioral and physiological effects of prolonged amphetamine intoxication.
描述了一种缓释苯丙胺微丸，它由一个硅胶囊组成，该胶囊在聚乙二醇中含有d-苯丙胺碱。当皮下植入大鼠体内时，这种微丸产生的脑内药物水平最初与2mg/kg硫酸d-苯丙胺腹腔注射剂量相当；这些水平逐渐下降，但在脑内仍有相当量的苯丙胺存在超过10天。植入这些微丸的大鼠在稳定仪中表现出持续2 - 3天的运动刻板行为和持续的多动。植入后四天，即使脑内仍有苯丙胺，活动也下降到接近对照水平。在这个后期阶段，大鼠表现出夸张的惊吓反应并抗拒处理。这种微丸是研究长期苯丙胺中毒的行为和生理影响的独特工具。
