Greenberg B D, Segal D S
Pharmacol Biochem Behav. 1985 Jul;23(1):99-105. doi: 10.1016/0091-3057(85)90137-6.
Amphetamine and phencyclidine (PCP) are both proposed to exert effects on unconditioned behavior through dopaminergic mechanisms. However, a relatively complete characterization of their effects in rats reveals markedly different response profiles. Furthermore, whereas acute co-administration of amphetamine and PCP resulted in an increase in one component of stereotypy, repetitive head movements, two measures of locomotor activation, i.e., ambulation and nonfocused sniffing, were unchanged, and rearings were reduced. In addition, the response alterations which occur with repeated administration of these drugs did not display cross-sensitization. Thus, although repeated daily injections of amphetamine, which produced progressive locomotor augmentation, sensitized animals to the locomotor-stimulating effects of PCP, repeated PCP treatment, which also resulted in locomotor augmentation, decreased the locomotor response to a challenge injection of amphetamine. These findings suggest significant differences in the mechanisms underlying the effects of acute and repeated administration of PCP and amphetamine.
苯丙胺和苯环己哌啶（PCP）都被认为是通过多巴胺能机制对非条件行为产生影响。然而，对它们在大鼠体内作用的相对完整的表征显示出明显不同的反应模式。此外，虽然苯丙胺和PCP的急性联合给药导致刻板行为的一个组成部分——重复性头部运动增加，但两种运动激活指标，即行走和非聚焦嗅探，并未改变，且竖毛行为减少。此外，重复给药这些药物时出现的反应改变并未表现出交叉致敏。因此，尽管每天重复注射苯丙胺会产生渐进性运动增强，并使动物对PCP的运动刺激作用敏感，但重复给予PCP（同样导致运动增强）会降低动物对苯丙胺激发注射的运动反应。这些发现表明，PCP和苯丙胺急性和重复给药作用的潜在机制存在显著差异。
