Wiwanitkit Viroj
Faculty of Medicine, Department of Laboratory Medicine, Chulalongkorn University, Bangkok, Thailand.
J Indian Med Assoc. 2008 Mar;106(3):168, 186.
Bird flu or avian flu is a new emerging Infectious disease. The H5N1 virus has not only affected the fowls but also the human beings. Severe disease with high mortality in humans in Vietnam and Thailand are reported. This mini-study was undertaken in order to document the Impact of bird flu infection on leucocyte and lymphocyte counts among patients of Thailand. This study was designed as a descriptive retrospective study. A literature review on the papers concerning human bird flu in Thailand was performed. According to this study, there are 6 cases covering 12 Thai patients with confirmed diagnosis of bird flu. However, the complete data were available on only 6 patients. The reported leucocyte count ranges from 1,200 cells/cmm to 5,680 cells/cmm and the lymphocyte count ranges from 454 cells/ cmm to 1,440 cells/cmm. The average leucocyte and lymphocyte counts equalled to 3,230.0 +/- 1,552.7 cells/cmm and 748.7 +/- 348.5 cells/cmm, respectively. According to this study, low lymphocyte count is common. This can support the previous observation for the lymphocyte suppression effect of H5N1 virus.
禽流感是一种新出现的传染病。H5N1病毒不仅感染禽类,也感染人类。越南和泰国报告了人类感染禽流感后出现的严重疾病和高死亡率情况。开展这项小型研究是为了记录禽流感感染对泰国患者白细胞和淋巴细胞计数的影响。本研究设计为描述性回顾性研究。对泰国有关人类禽流感的论文进行了文献综述。根据这项研究,有6个病例涵盖12名确诊感染禽流感的泰国患者。然而,仅有6名患者有完整数据。报告的白细胞计数范围为1200个细胞/立方毫米至5680个细胞/立方毫米,淋巴细胞计数范围为454个细胞/立方毫米至1440个细胞/立方毫米。白细胞和淋巴细胞的平均计数分别为3230.0±1552.7个细胞/立方毫米和748.7±348.5个细胞/立方毫米。根据这项研究,淋巴细胞计数低很常见。这可以支持之前关于H5N1病毒对淋巴细胞抑制作用的观察结果。