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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Someya T, Shibasaki M, Kato T, Noguchi T, Ishida N, Takahashi S

Department of Psychiatry, Shiga University of Medical Science, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(2):275-8. doi: 10.1016/0278-5846(91)90092-f.

We measured haloperidol reductase activity in red blood cells in 87 samples collected from 50 Japanese psychiatric patients on HAL. HAL reductase activities in the patients were in a range of 7.9-26.1 pmol/hr/10(6) RBC (mean = 13.4, S.D. = 3.4). Interindividual variability was as large as 25.4% (CVs), while intraindividual CVs were small (8.9%). 2. Distribution of HAL reductase activities was normal but their values were slightly lower in the patients than those in the normal controls, though the difference between these two groups was not significant. 3. No significant correlations were found between HAL reductase activity in RBC vs dose of HAL per body weight, or plasma and RBC RHAL/HAL ratio.

我们检测了从50名服用氟哌啶醇（HAL）的日本精神病患者采集的87份样本中红细胞内的氟哌啶醇还原酶活性。患者的氟哌啶醇还原酶活性范围为7.9 - 26.1 pmol/小时/10⁶个红细胞（平均值 = 13.4，标准差 = 3.4）。个体间变异性高达25.4%（变异系数），而个体内变异系数较小（8.9%）。2. 氟哌啶醇还原酶活性分布呈正态分布，但其值在患者中略低于正常对照组，尽管两组之间的差异不显著。3. 红细胞内氟哌啶醇还原酶活性与每体重氟哌啶醇剂量、血浆及红细胞中RHAL/HAL比值之间均未发现显著相关性。

Someya T, Shibasaki M, Kato T, Noguchi T, Ishida N, Takahashi S

Department of Psychiatry, Shiga University of Medical Science, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(2):275-8. doi: 10.1016/0278-5846(91)90092-f.

We measured haloperidol reductase activity in red blood cells in 87 samples collected from 50 Japanese psychiatric patients on HAL. HAL reductase activities in the patients were in a range of 7.9-26.1 pmol/hr/10(6) RBC (mean = 13.4, S.D. = 3.4). Interindividual variability was as large as 25.4% (CVs), while intraindividual CVs were small (8.9%). 2. Distribution of HAL reductase activities was normal but their values were slightly lower in the patients than those in the normal controls, though the difference between these two groups was not significant. 3. No significant correlations were found between HAL reductase activity in RBC vs dose of HAL per body weight, or plasma and RBC RHAL/HAL ratio.

我们检测了从50名服用氟哌啶醇（HAL）的日本精神病患者采集的87份样本中红细胞内的氟哌啶醇还原酶活性。患者的氟哌啶醇还原酶活性范围为7.9 - 26.1 pmol/小时/10⁶个红细胞（平均值 = 13.4，标准差 = 3.4）。个体间变异性高达25.4%（变异系数），而个体内变异系数较小（8.9%）。2. 氟哌啶醇还原酶活性分布呈正态分布，但其值在患者中略低于正常对照组，尽管两组之间的差异不显著。3. 红细胞内氟哌啶醇还原酶活性与每体重氟哌啶醇剂量、血浆及红细胞中RHAL/HAL比值之间均未发现显著相关性。