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东方精神病患者红细胞中氟哌啶醇还原酶活性及血浆中还原型氟哌啶醇/氟哌啶醇比率的测定。

Measurement of haloperidol reductase activity in red blood cells and reduced haloperidol/haloperidol ratios in plasma in oriental psychiatric patients.

作者信息

Shibasaki M, Someya T, Kato T, Noguchi T, Ishida N, Takahashi S

机构信息

Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(6):941-7. doi: 10.1016/0278-5846(90)90079-v.

DOI:10.1016/0278-5846(90)90079-v
PMID:2277853
Abstract
  1. The authors established a method for measuring haloperidol (HAL) reductase activity in human red blood cells. 2. Characteristics of the HAL reductase in red blood cells were examined. This enzyme reaction was NADPH dependent, and the optimum pH was at 8.2-8.9. Vmax and Km were calculated as 25-150 pmol/hr/10(6) RBC and 160-2600 microM respectively. 3. HAL reductase activities in red blood cells from 14 patients treated with HAL were in a range of 9.7-20.8 pmol/hr/10(6) RBC. So far we did not find any significant correlation between HAL reductase activities and reduced HAL/HAL ratios in plasma.
摘要
  1. 作者建立了一种测量人红细胞中氟哌啶醇（HAL）还原酶活性的方法。2. 对红细胞中HAL还原酶的特性进行了研究。该酶反应依赖于NADPH，最适pH值为8.2 - 8.9。Vmax和Km分别计算为25 - 150 pmol/小时/10(6)个红细胞和160 - 2600微摩尔。3. 14例接受HAL治疗患者的红细胞中HAL还原酶活性在9.7 - 20.8 pmol/小时/10(6)个红细胞范围内。到目前为止，我们尚未发现HAL还原酶活性与血浆中HAL还原型/HAL比值之间存在任何显著相关性。

相似文献

1
Measurement of haloperidol reductase activity in red blood cells and reduced haloperidol/haloperidol ratios in plasma in oriental psychiatric patients.东方精神病患者红细胞中氟哌啶醇还原酶活性及血浆中还原型氟哌啶醇/氟哌啶醇比率的测定。
Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(6):941-7. doi: 10.1016/0278-5846(90)90079-v.
2
Haloperidol reductase activity in red blood cells from oriental patients on haloperidol.服用氟哌啶醇的东方患者红细胞中的氟哌啶醇还原酶活性。
Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(2):275-8. doi: 10.1016/0278-5846(91)90092-f.
3
Relation of plasma and red blood cells reduced haloperidol concentrations to haloperidol reductase activity assayed in red blood cells in psychiatric population.
Prog Neuropsychopharmacol Biol Psychiatry. 1993 Mar;17(2):257-67. doi: 10.1016/0278-5846(93)90046-u.
4
[Erythrocyte ketone reductase activity, total plasma haloperidol and acute psychoses].[红细胞酮还原酶活性、血浆总氟哌啶醇与急性精神病]
Encephale. 1995 Nov-Dec;21(6):417-24.
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Haloperidol metabolism in psychiatric patients: importance of glucuronidation and carbonyl reduction.精神科患者中氟哌啶醇的代谢：葡萄糖醛酸化和羰基还原的重要性。
J Clin Psychopharmacol. 1992 Jun;12(3):169-74.
6
[Value of the determination of erythrocyte haloperidol ketone reductase activity in the evaluation of haloperidol therapy].[红细胞氟哌啶醇酮还原酶活性测定在氟哌啶醇治疗评估中的价值]
Therapie. 1994 Jan-Feb;49(1):71-4.
7
Haloperidol reduction can be assayed in human red blood cells.氟哌啶醇的减少量可在人类红细胞中进行测定。
Can J Physiol Pharmacol. 1989 Nov;67(11):1468-9. doi: 10.1139/y89-237.
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Pharmacoclinical correlations in schizophrenic patients treated with haloperidol decanoate: clinical evaluations, concentrations of plasma and red blood cell haloperidol and its reduced metabolite, and plasma homovanillic acid.用癸酸氟哌啶醇治疗的精神分裂症患者的药效临床相关性：临床评估、血浆和红细胞中氟哌啶醇及其还原代谢物的浓度以及血浆高香草酸。
Prog Neuropsychopharmacol Biol Psychiatry. 1995 Nov;19(7):1119-35. doi: 10.1016/0278-5846(95)00230-8.
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Ketone reductase activity and reduced haloperidol/haloperidol ratios in haloperidol-treated schizophrenic patients.
Psychiatry Res. 1995 Jul 28;57(2):101-8. doi: 10.1016/0165-1781(95)02633-8.
10
Interindividual variation in bromperidol metabolism and relationship to therapeutic effects.
J Clin Psychopharmacol. 2000 Apr;20(2):175-80. doi: 10.1097/00004714-200004000-00009.

引用本文的文献

1
Pharmacokinetics of haloperidol: an update.氟哌啶醇的药代动力学：最新进展。
Clin Pharmacokinet. 1999 Dec;37(6):435-56. doi: 10.2165/00003088-199937060-00001.
2
Reduced haloperidol: a factor in determining the therapeutic benefit of haloperidol treatment?氟哌啶醇用量减少：决定氟哌啶醇治疗疗效的一个因素？
Psychopharmacology (Berl). 1992;106(3):289-96. doi: 10.1007/BF02245407.