人类精浆的主要杀菌活性依赖于锌，且源于精液凝胶蛋白的片段化。
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
作者信息
Edström Anneli M L, Malm Johan, Frohm Birgitta, Martellini Julie A, Giwercman Aleksander, Mörgelin Matthias, Cole Alexander M, Sørensen Ole E
机构信息
Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
出版信息
J Immunol. 2008 Sep 1;181(5):3413-21. doi: 10.4049/jimmunol.181.5.3413.
One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual intercourse. Moreover, the antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH. These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma.
精浆的主要作用之一是为女性生殖道中的精子提供抗菌保护。我们发现，精液凝块溶解后精浆的杀菌活性最高，随后这种抗菌活性大大降低。抗菌活性源自精液凝胶蛋白片段化产生的肽，而精液凝胶蛋白全蛋白没有抗菌活性。射精后，精液凝胶蛋白衍生的肽随着时间的推移逐渐碎片化，从而失去抗菌活性。这与体外和性交后全精浆抗菌活性的丧失情况相似。此外，在中性和低pH条件下，精浆中产生的精液凝胶蛋白衍生肽的抗菌活性都严格依赖于锌。这些数据揭示了精液凝块溶解以及人类精浆中高锌浓度的新作用。
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