Hassan Mohamed, Flanagan Thomas W, Eshaq Abdulaziz M, Altamimi Osama K, Altalag Hassan, Alsharif Mohamed, Alshammari Nouf, Alkhalidi Tamadhir, Boulifa Abdelhadi, El Jamal Siraj M, Haikel Youssef, Megahed Mossad
Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.
Department of Operative Dentistry and Endodontics, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France.
Cancers (Basel). 2025 Feb 28;17(5):843. doi: 10.3390/cancers17050843.
Prostate cancer (PCa) accounts for roughly 15% of diagnosed cancers among men, with disease incidence increasing worldwide. Age, family history and ethnicity, diet, physical activity, and chemoprevention all play a role in reducing PCa risk. The prostate is an exocrine gland that is characterized by its multi-functionality, being involved in reproductive aspects such as male ejaculation and orgasmic ecstasy, as well as playing key roles in the regulation of local and systemic concentrations of 5α-dihydrotestosterone. The increase in androgen receptors at the ventral prostate is the first elevated response induced by copulation. The regulation of prostate growth and function is mediated by an androgen-dependent mechanism. Binding 5-DHT to androgen receptors (AR) results in the formation of a 5α-DHT:AR complex. The interaction of the 5α-DHT:AR complex with the specific DNA enhancer element of androgen-regulated genes leads to the regulation of androgen-specific target genes to maintain prostate homeostasis. Consequently, ejaculation may play a significant role in the reduction of PCa risk. Thus, frequent ejaculation in the absence of risky sexual behavior is a possible approach for the prevention of PCa. In this review, we provide an insight into possible mechanisms regulating the impact of frequent ejaculation on reducing PCa risk.
前列腺癌（PCa）约占男性确诊癌症的15%，且全球疾病发病率呈上升趋势。年龄、家族病史和种族、饮食、身体活动以及化学预防均在降低PCa风险中发挥作用。前列腺是一种外分泌腺，其特点是具有多功能性，参与男性射精和性高潮等生殖方面，以及在调节局部和全身5α-二氢睾酮浓度方面发挥关键作用。腹侧前列腺雄激素受体的增加是交配诱导的首个升高反应。前列腺生长和功能的调节由雄激素依赖性机制介导。5-二氢睾酮与雄激素受体（AR）结合会导致形成5α-二氢睾酮：AR复合物。5α-二氢睾酮：AR复合物与雄激素调节基因的特定DNA增强子元件相互作用，导致对雄激素特异性靶基因的调节，以维持前列腺内环境稳定。因此，射精可能在降低PCa风险中起重要作用。所以，在没有危险性行为的情况下频繁射精是预防PCa的一种可能方法。在本综述中，我们深入探讨了调节频繁射精对降低PCa风险影响的可能机制。
