性早熟的

[Precocious pubertal].

作者信息

Carel Jean-Claude, Zenaty Delphine, Paulsen Anne, Simon Dominique, Léger Juliane

机构信息

Service d'endocrinologie-diabétologie pédiatrique, centre de référence des maladies endocriniennes rares de la croissance, hôpital Robert-Debré, Université Paris-Diderot Paris-7, 75935 Paris Cedex 19, France.

出版信息

Rev Prat. 2008 Jun 30;58(12):1317-23.

PMID:18714652

Abstract

Precocious pubertal is frequent and should lead to a rigorous evaluation. It is important to precisely evaluate the timing of pubertal development, and to search for an hypothalamic lesion in cases of central precocious puberty. It is also important to recognize that many cases of precocious puberty will not progress and therefore do not need treatment. When central precocious puberty has been confirmed, GnRH agonists should be considered. Management issues, as well as long term results of these treatments are presented.

摘要

性早熟很常见，应进行严格评估。准确评估青春期发育的时间很重要，对于中枢性性早熟病例，要查找下丘脑病变。同样重要的是要认识到，许多性早熟病例不会进展，因此无需治疗。确诊中枢性性早熟后，应考虑使用促性腺激素释放激素（GnRH）激动剂。本文介绍了这些治疗的管理问题以及长期效果。